End Of The Study Research Articles

Assessment of School Teacher's Disaster Preparedness by Using Comprehensive School Safety Framework

The Comprehensive School Safety Framework (CSSF) is a comprehensive strategy for a safe learning environment for teachers, students and school staff. This study assessed the disaster preparedness level of secondary school teachers in the public school district Attock. Three hundred twenty teachers were selected from district Attock public based on their age, gender, qualification, teaching level and teaching experience. A five-point Likert scale survey instrument using the CSS framework was used to analyze the disaster preparedness of secondary school teachers. The data was collected through Google Forms using a survey. Data was standardized on MS Excel for a smooth run on SPPS. The data revealed that the majority of the schools are prepared for disaster. There are safe learning facilities, school disaster management, disaster risk reduction and resilience education. However, no school was found to be highly prepared. At the end of the study, the researcher gives further research recommendations on school safety based on the CSS framework.

The relationship between psychological distress and weight maintenance in weight cycling: mediating role of eating behavior

BackgroundObesity is a global public health concern. The goal of this study was to see if eating habits could mediate the relationship between psychological distress and weight maintenance in a population with a history of weight cycling.MethodsA 3-month outpatient intervention consisting of a diet and exercise program was provided to 153 participants. Psychological distress, appetite, and behavior were assessed at the beginning and end of the study. Anthropometric measurements were taken at baseline and six months.ResultsAfter the structural equation model was developed, it was discovered that the psychological status of people with obesity and weight cycling histories correlated with the weight loss outcome effect (three and six months). This effect was mediated by factors related to eating behavior. Associative psychological factors had a direct effect on eating behavior (three months: β = 0.181, 95% CI: 0.055–0.310; six months: β = 0.182, 95% CI: 0.039–0.332) and appetite had a direct effect on eating behavior (three months: β = 0.600, 95% CI: 0.514–0.717; six months: β = 0.581, 95% CI: 0.457–0.713), both of which were significant (p < 0.01). At three months, psychological distress has a more substantial positive impact on weight change, with eating behavior acting as a partial mediator. At six months, there was no support for appetite’s moderating role in eating behavior.ConclusionsThe findings suggest that psychological interventions should be strengthened to improve weight loss effectiveness, particularly in participants with a history of weight cycling, making weight loss more complicated and prone to rebound.Clinical trial registrationThe study has been registered in Clinical Trials (NCT05311462).

Sustaining Patency of Peripherally Inserted Venous Catheter (PIVC) among Patients in Continuous Intra Venous Therapy

Background: Phlebitis is still a common complication of peripheral venous catheters. Finding a suitable solution to prevent and reduce the incidence of this complication continues to be a challenge. Various strategies were used to reduce the incidence of phlebitis. Mostly non-pharmacological measures were taken as first preference. Intially, when patients come to any hospital for their treatment, the first is the peripherally inserted venous catheter access conducted inpatient for medication administration, fluid administration and blood transfusion in both the hospital setting and ambulatory setting. About 70% of thepatients admitted to the hospital requires peripherally inserted venous catheters (PIVCs). The incidence of phlebitis is higher in patients who undergo continuous intravenous therapy. Objectives: To find out the effect of hand grip exercise in the sustaining patency of peripherally inserted venous catheters among patients in continuous intravenous therapy. Methods: During the 8 weeks the hand grip exercise was evaluated in patients, who had undergone continuous intravenous infusion through the peripherally inserted venous catheter for at least 3 days. The measurement of data is based on the patient’s socio-demographic Performa, patency checklist, visual infusion phlebitis score and visual analogue scale. The post-test was conducted in both experimental and control groups. Result: Till the end of the study, 76 participants were taken. On day 3 of the hand grip exercise maximum of 24 (61.5%) PIVC were patent, whereas in control group 5 (13.5%) PIVC were able to maintain their patency. On day 5 of exercise 34 (91.9%) PIVC were replaced with a cause of phlebitis 33(89.2%) in the control group in comparison with the experimental group only 22 (56.4%) lines were replaced with the same cause of phlebitis 24 (61.5%). Conclusion: Hand grip exercise is important for clients, to reduce the need for the potentially painful process of placing vascular lines and also helps to control costs by reducing the number of devices used for each client and the development of phlebitis.

Features of the influence of special strength training on performance in competitive activities in Mixed Martial Arts (example of horting)

The article is devoted to the study of the problem of the specific influence of strength training in horting on the effectiveness of the implementation of the functional adaptation potential of the athletes' body and their level of technical and tactical skill in the process of competitive activity. In the process of the research, a comparative analysis of the results of the matches between the athletes of all three experimental groups identified at the stage of selection for the championship of Ukraine was carried out after three months of using experimental models of strength training classes and during the competition for the selection for the Cup of Ukraine. The results of the study showed that the number of victories of athletes of the second group at this stage of the study during qualifying matches decreased by 41.7% compared to the previous results. At that time, on the contrary, among the athletes of the third group, we observe an increase in the effectiveness of competitive activity by 62.5% compared to the number of victories recorded during qualifying matches for the championship of Ukraine before the use of the experimental model of strength training classes. In the process of analyzing the results of competitive activity recorded in at the end of the study, during qualifying matches for the Cup of Ukraine, it was found that among the athletes of the second group, compared to the magnificent indicators of the previous control, we observed the largest decrease in the number of victories by 4 times due to technical knockout. At the same time, among the athletes of this group, the indicator of the number of victories obtained due to knockout decreased by 50.0% compared to the results that were revealed during the qualifying competitions before the start of the application of the proposed experimental model of training sessions. The corresponding negative dynamics to a 3-fold decrease in the number of victories obtained in matches with athletes of the third group in the conditions of the use of suffocating techniques, we record in the participants of the second group at this stage of the study compared to the results found in previous competitions.

Abstract 3924: Dual COX-2/sEH inhibition enhances immunotherapy and chemotherapy to induce bladder cancer regression

Abstract Unresolved inflammation plays a critical role in bladder cancer initiation and progression. Chemotherapy (e.g. gemcitabine and cisplatin), the standard of care for advanced bladder cancer, disrupts inflammation resolution and is only partially effective in preventing tumor recurrence after treatment. Immunotherapy has emerged as a potential treatment option for bladder cancer patients, however it is ineffective in 80% of patients and can induce a pro-inflammatory cytokine storm. Therefore, there is a critical unmet medical need to improve chemotherapy and immunotherapy in bladder cancer. To address this, we have developed dual COX-2/sEH inhibitors (e.g. PTUPB). This lead compound is representative of a newly patented class of “dual acting” molecules that target two important enzymes in the arachidonic acid cascade with nanomolar binding affinity: cyclooxygenase-2 (COX-2) and soluble epoxide hydrolase (sEH). Oral dosing of PTUPB is well-tolerated in animal models. Since chemotherapy and immunotherapy both induce tumor-promoting inflammation via an eicosanoid/cytokine storm, we hypothesized that dual COX-2/sEH inhibition would enhance immunotherapy in experimental bladder cancer via anti-inflammatory mechanisms. When syngeneic (MB49) bladder tumors reached ~200 mm3 in immunocompetent mice, treatment was initiated with PTUPB, anti-CTLA-4, anti-PD1, gemcitabine &amp; cisplatin, or various combinations thereof. Here we demonstrate that chemotherapy and/or immunotherapy stimulated sEH and COX-2 expression in tumor tissue which was counter-regulated by PTUPB. While monotherapy treatment with PTUPB, gemcitabine &amp; cisplatin, anti-PD1 or anti-CTLA-4 suppressed tumor growth compared to control, the tumors escaped single treatments by the end of the study. Remarkably, dual COX-2/sEH inhibition in combination with chemotherapy (gemcitabine and cisplatin) and/or immune checkpoint blockade (anti-CTLA-4 or anti-PD1) induced sustained tumor regression via synergistic anti-tumor activities. Chemotherapy and/or immunotherapy induced the expression of ER stress response genes (e.g. BiP and CHOP) and angiogenic factors (e.g. EGF and VEGF-C) in bladder cancer tissue, which were repressed by PTUPB. PTUPB also prevented chemotherapy-induced toxicity and prolonged survival in an orthotopic MB49 tumor model. Taken together, our results demonstrate dual COX-2/sEH inhibition as a novel therapeutic approach to enhance immunotherapy in bladder cancer without overt toxicity. Citation Format: Kimberly Lupita Vazquez, Eva Rothenberger, Weicang Wang, Sung Hee Hwang, Diane R. Bielenberg, Bruce D. Hammock, Dipak Panigrahy. Dual COX-2/sEH inhibition enhances immunotherapy and chemotherapy to induce bladder cancer regression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3924.

Converting laundry work of women in underdeveloped countries from risk of musculoskeletal disorders to a sustainable intervention: A design with holistic approach

AbstractMore than half of the population in impoverished areas around the world, which lack sufficient energy and water, do not have washing machines. Due to a lack of resources and economic reasons, the mechanical task of modern washing machines requiring electrical energy can only be done through hand washing. Additionally, water fetching and laundry work are predominately assigned to women due to socio‐cultural dynamics in disadvantaged areas. The repetitive motions involved in washing over extended periods of time, coupled with awkward body positions, often lead to musculoskeletal disorders in women. This study aims to improve women's work safety and living conditions through a product design for laundry washing. First, the ergonomic risk associated with women's body postures while washing clothes on the floor was evaluated to better understand the impact of the intervention and rapid upper extremity assessment (RULA) method was used for this purpose. Subsequently, the design process for a manual washing product, which operates without electricity, can handle bulk laundry and facilitates easier and more ergonomic work instead of directly scrubbing clothes, was initiated as a remedial intervention. Recognizing that laundry work is a multidimensional experience in women's lives beyond its ergonomic aspects, a holistic design methodology was adopted, incorporating various design approaches to create concepts that better integrate with the lives of woman users. Insights gained from these design approaches were then combined with the conceptual design method to generate design proposals. At the end of the study, the developed manual washing machine design performed improved RULA analysis scores and biomechanical loading outcomes compared to hand washing.

The effects of biological and chemical silver nanoparticles along with aerobic and anaerobic training protocols on tissues: Morphological and histopathological evaluation.

Nanotechnology and its byproducts are used increasingly considering its global nanotechnology market size and many applications in the health field. The aim of the present study was to investigate the effect of aerobic and anaerobic exercises on cellular uptake of nanoparticles in body tissues. Fusarium oxysporum was used to synthesize biological AgNPs in silver nitrate solution and UV-vis spectrophotometer; XRD and TEM were used to confirm production of nanoparticles. Moreover, 45 male Wistar rats were purchased and randomly divided into 9 equal groups including healthy control groups, aerobic preparation, anaerobic preparation, biological AgNPs, chemical AgNPs, biological AgNPs+aerobic preparation, biological AgNPs+anaerobic preparation, chemical AgNPs+ aerobic preparation, chemical AgNPs+anaerobic preparation. In order to induce aerobic and anaerobic preparation and to create tissue adaptations, male rats completed two types of aerobic and anaerobic protocols three sessions per week for 10 weeks. At the end of the study, sampling was done for histopathology study. The size and shape of AgNPs was 20-30 nm and spherical to polygonal, respectively. The results showed that anaerobic exercise was significantly effective in weight loss. The chemical nanoparticle group led to more intensive tissue degradation in all variables and there were no significant tissue changes in the aerobic, anaerobic, the biological nanoparticles + aerobic and anaerobic groups. It seems that biological AgNPs are more effective than chemical AgNPs on body tissues and chemical AgNPs lead to more tissue damage in most variables. RESEARCH HIGHLIGHTS: There were severe degradative histological effects in the chemical AgNPs groups compare biological AgNPs groups, in terms of most variables.

The paradox of spring: Thyroid and glucocorticoid responses to cold temperatures and food availability in free living Carneddau ponies

In seasonal environments, maintaining a constant body temperature poses challenges for endotherms. Cold winters at high latitudes, with limited food availability, create opposing demands on metabolism: upregulation preserves body temperature but depletes energy reserves. Examining endocrine profiles, such as thyroid hormone triiodothyronine (T3) and glucocorticoids (GCs), proxies for changes in metabolic rate and acute stressors, offer insights into physiological trade-offs. We evaluated how environmental conditions and gestation impact on faecal hormone metabolites (fT3Ms and fGCMs) from late winter to spring in a free-living population of Carneddau ponies. Faecal T3Ms were highest in late February and March, when temperatures were lowest. Then, fT3Ms concentrations decreased throughout April and were at the lowest in May before increasing towards the end of the study. The decline in fT3M levels in April and May was associated with warmer weather but poor food availability, diet diversity and diet composition. On the other hand, fGCM levels did not display a clear temporal pattern but were associated with reproductive status, where pregnant and lactating females had higher fGCM levels as compared to adult males and non-reproductive females. The temporal profile of fT3Ms levels highlights metabolic trade-offs in a changing environment. In contrast, the ephemeral but synchronous increase in fGCM concentrations across the population suggest a shared experience of acute stressors (i.e., weather, disturbance or social). This multi-biomarker approach can evaluate the role of acute stressors versus energy budgets in the context of interventions, reproduction, seasonality and environmental change, or across multiple scales from individuals to populations.

Docosahexaenoic acid reduced vascular endothelial cell injury in diabetic rats via the modulation of autophagy

Purpose: Among varied ω-3 polyunsaturated fatty acid types, the therapeutic properties of Docosahexaenoic acid (DHA) have been indicated under diabetic conditions in different cell lineages. Here, we investigated the anti-diabetic properties of DHA in rats with type 2 diabetes mellitus (D2M) focusing on autophagy-controlling factors. Methods: D2M was induced in male Wistar rats using a single dose of Streptozocin (STZ) and a high-fat diet for 8 weeks. On week 2, diabetic rats received DHA 950 mg/kg/day until the end of the study. After that, rats were euthanized, and aortic and cardiac tissue samples were stained with H&amp;E staining for histological assessment. The expression of adhesion molecules, ICAM-1 and VCAM-1, was measured in heart samples using real-time PCR analysis. Using western blotting, protein levels of BCLN1, LC3, and P62 were measured in D2M rats pre- and post-DHA treatment. Results: Data showed intracellular lipid vacuoles inside the vascular cells, and cardiomyocytes, after induction of D2M and DHA reduced intracellular lipid droplets and in situ inflammatory response. DHA can diminish increased levels of ICAM-1 in diabetic conditions (pControl VS. D2M rats = 0.005) and reach near-to-control values (pControl VS. D2M rats = 0.28; pD2M rats VS. D2M rats + DHA =0.033). Based on western blotting, D2M slightly increased the BCLN1 and LC3-II/I ratio without affecting P62. DHA promoted the LC3II/I ratio (p = 0.303) and reduced P62 (pControl VS. D2M rats + DHA =0.0433; pD2M VS. D2M rats + DHA =0.096), leading to the completion of autophagy flux under diabetic conditions. Conclusion: DHA can reduce lipotoxicity of cardiovascular cells possibly via the activation of adaptive autophagy response in D2D rats.

Digital and online tools employed by prospective teachers to access information

The proliferation of digital information technologies has underscored the heightened necessity for online information search. This study is directed towards the analysis of the strategies adopted by prospective teachers in the selection of digital content employed for accessing information, their preferences concerning the use of digital and online tools, and the rationale that underpins these preferences. To achieve this aim, the case study method was used. Employing the purposive sampling method, the study involved a participant pool of 72 teacher candidates in the 3rd and 4th grades within the faculties of education. To collect data, a personal information form, an online interview form, a focus group interview form, and a word association test were employed. The data were analyzed using the content and descriptive analysis methods. At the end of the study, the prospective teachers expressed a common tendency that when it comes to scientific research, they often prefer to search for articles whereas for more general inquiries, they have a propensity for utilizing internet searches. Most of the prospective teachers follow a step-by-step research process when accessing information. In addition, they employ both goal-oriented and general-content resources while in pursuit of scientific information. They pay attention to data reliability, accurate information, speed, and access to the Internet in the process of obtaining information. They consider the tools they use adequate and reliable. Teacher candidates establish complex conceptual networks among the array of tools they employ to access information. A comprehensive discussion concerning the outcomes of the research is also presented.

Ameliorative Effect of Cinnamon and Rosemary Oils in Acrylamide–Induced Hepatic Injury in Rats

Liver diseases can result from various causes, such as viruses, bacteria, autoimmune disorders, or certain medications and toxic substances. While modern medicine offers treatments for these conditions, there needs to be more effective drugs that can protect and regenerate liver cells. Therefore, it is crucial to identify new treatment options and liver-protective agents that are both highly efficient and safe. This study is assigned to investigate the adverse effects of acrylamide on the liver in rats and explore whether these effects can be mitigated by co-administration of cinnamon oil (C.O.), rosemary oil (R.O.), or a combination of both oils during acrylamide exposure. A total of 70 male albino rats were divided randomly into 7 groups, each group of 10 rats, that received different treatments: control group, acrylamide-treated group (20 mg/kg b.wt), cinnamon oil-treated group (200 mg/kg b.wt), rosemary oil-treated group (250 mg/kg b.wt), acrylamide and cinnamon oil-treated group, acrylamide and rosemary oil-treated group, and acrylamide, cinnamon oil, and Rosemary oil-treated group. These treatments were administered orally for 28 consecutive days. Blood and liver tissue samples were gathered at the end of the study to assess the outcomes. The results revealed that cinnamon oil and rosemary oils exhibited hepatoprotective effects, as evidenced by normalized liver function parameters (alanine transaminase, Aspartate transaminase, and Alkaline phosphatase), as well as improvements in nonenzymatic parameters (total protein, albumin, cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein). The observed hepatoprotection of cinnamon oil and rosemary oils was attributed to their ability to reduce oxidative stress caused by acrylamide, as demonstrated by lower levels of liver cell lipid peroxidation product (malondialdehyde) and enhanced activity of antioxidative enzymes (glutathione and catalase) in liver tissue. Keywords: Cinnamon, Rosemary, Acrylamide, Liver, Rats, Antioxidants

Comparison of the effectiveness of project-based 6E learning and problem-based quantum learning: Solomon four-group design

PurposeResearchers have previously utilized the project-based 6E learning model and the problem-based quantum learning model in various courses, such as the instructional principles and methods course and the character and values education course. These models were evaluated for their impact on students in different subjects, including developing skills, values, democracy perceptions, attitudes towards cooperative learning, metacognitive thinking skills and teacher self-efficacy perceptions. In 2023, Ökmen, Sahin and Kiliç reported positive outcomes, while Sahin and Kiliç reported similar findings in 2023a, 2023b and 2023c. There has been no investigation into how the models affect students' critical thinking and academic literacy. This study seeks to determine the impact of both models on these skills, gain more insight into their effectiveness and determine which is more beneficial. The results will guide the decision-making process for the character and values education course and other courses in the future. Specifically, this research aims to compare the effects of the project-based 6E learning model and problem-based quantum learning model on critical thinking and academic literacy.Design/methodology/approachThis research employed the Solomon four-group experimental design to assess the efficacy of the applications. Prior knowledge and experience of the participants were evaluated through pretests. However, it should be noted that pretests may impact posttest scores either positively or negatively. For instance, participants taking the test multiple times may become more interested or attentive to the subject matter. The Solomon four-group design was deemed appropriate to analyze the influence of pretesting. This design enables the investigation of the application effect, pretest effect and interactive effect of pretest and application (van Engelenburg, 1999).FindingsIt was concluded that the project-based 6E learning model was effective in developing critical thinking in students, but not significantly. It was concluded that the problem-based quantum learning model significantly improved students' critical thinking skills. It was concluded at the end of the study that the project-based 6E learning model notably enhanced students' academic literacy. It was concluded that the problem-based quantum learning model had a significant positive impact on students' academic literacy. According to research, it has been determined that the problem-based quantum learning model is superior in enhancing critical thinking abilities compared to the project-based 6E learning model. Nevertheless, there seems to be no detectable disparity in the academic literacy advancement of pupils between the problem-based quantum learning model and the project-based 6E learning model.Originality/valueThere has been no investigation into how the models affect students' critical thinking and academic literacy. This study seeks to determine the impact of both models on these skills, gain more insight into their effectiveness and determine which is more beneficial. The results will guide the decision-making process for the character and values education course and other courses in the future.

Siglec15/TGF‐β bispecific antibody mediates synergistic anti‐tumor response against 4T1 triple negative breast cancer in mice

AbstractAn ideal tumor‐specific immunomodulatory therapy should both preferentially target the tumor, while simultaneously reduce the immunosuppressive environment within the tumor. This guiding principle led us to explore engineering Siglec‐15 (S15) targeted bispecific antibody (bsAb) to enhance therapy against triple negative breast cancer (TNBC). S15 appears to be exclusively expressed on macrophages and diverse tumor cells, including human and mouse 4T1 TNBC. TGF‐β is a growth hormone frequently associated with increased tumor invasiveness, including in TNBC. Here, to overcome the immune‐suppressive environment within TNBC tumors to enable more effective cancer therapy, we engineered a bispecific antibody (bsAb) targeting both Siglec15 and TGF‐β. In mice engrafted with orthotopic 4T1 tumors, S15/TGF‐β bsAb treatment was highly effective in suppressing tumor growth, not only compared to control monoclonal antibody (mAb) but also markedly more effective than mAbs against S15 alone, against TGF‐β alone, as well as a cocktail of both anti‐S15 and anti‐TGF‐β mAbs. We did not detect liver and lung metastasis in mice treated with S15/TGF‐β bsAb, unlike all other treatment groups at the end of the study. The enhanced anti‐tumor response observed with S15/TGF‐β bsAb correlated with a less immunosuppressive environment in the tumor. These results underscore S15‐targeted bsAb as a promising therapeutic strategy for TNBC, and possibly other S15 positive solid tumors.

Density affects rearing performance of juvenile landlocked fall Chinook Salmon

AbstractObjectiveDensity‐related information for landlocked fall Chinook Salmon Oncorhynchus tshawytscha shortly after first feeding is poorly understood. This study was undertaken to determine the effects of a range of rearing densities (low, intermediate, and high) on rearing performance and survival of newly feed‐trained juvenile landlocked fall Chinook Salmon.MethodsThe fish were reared for 66 days in 1.8‐m (diameter) tanks with approximate volume of 2036 L at one of three loadings of approximately 2500, 5000, or 10,000 fish/tank.ResultThe initial and final densities for each of the three loadings were 0.73 and 8.93, 1.45 and 16.41, and 2.90 and 26.86 kg/m3, respectively. At the end of the study, the specific growth rates were significantly lower, total lengths were significantly shorter, and feed conversion ratios were significantly greater in the fish from the highest‐density treatment relative to the fish in the other treatments. Percentage of weight gain, final weights, and condition factor were significantly reduced in fish from the highest‐density treatment relative those at the lowest density. There were no significant differences in any growth metrics between fish that were reared at the lowest and intermediate densities. The intermediate density (5000 fish/tank) produced intermediate results that did not significantly differ from either the highest or lowest densities. Mortality was not significantly different among the density treatments.ConclusionAn initial loading of 5000 fish in 1.8‐m (diameter) circular tanks, corresponding to initial and final densities of 1.45 and 16.41 kg/m3, respectively, is recommended to minimize the detrimental effects of density on newly feeding Chinook Salmon while maximizing their production in often limited hatchery space.

Efficacy of adjunctive octenidine hydrochloride as compared to chlorhexidine and placebo as adjuncts to instrumentation in stage I-II periodontitis: A double-blinded randomized controlled trial.

This randomized, controlled, double-blinded clinical trial aimed to evaluate the efficacy of octenidine hydrochloride and chlorhexidine mouthwashes as adjuncts to instrumentation in stage I-II periodontitis patients. Forty-five patients with mild-to-moderate periodontitis were randomly allocated to three groups: 0.1% octenidine dihydrochloride (OCT), placebo, and 0.12% chlorhexidine (CHX) mouthwashes. Patients were instructed to use the mouthwash after instrumentation for twice a day up to 3 weeks. Periodontal parameters such as probing pocket depth (PPD), clinical attachment loss (CAL), O'Leary plaque index (PI), Loe and Silness gingival index (GI), Lobene stain index (SI), and oral soft tissue changes were recorded at baseline and once every week for 3 weeks. The visual analogue scale (VAS) was also recorded as a self-administered questionnaire at the end of the study. The one-way ANOVA was used to compare VAS scores between the groups. The repeated measures ANOVA and post hoc Newman-Keuls tests were used to assess the differences in the periodontal parameters between groups at different time intervals. The Kruskal-Wallis test was used to compare the mean SI. There was a significant reduction in the mean GI of the OCT and CHX groups compared to placebo (p < 0.05). OCT usage resulted in significantly less staining, according to mean SI, when compared to CHX. Furthermore, VAS scores revealed that OCT was significantly the preferred mouthwash (p < 0.01). Adjunctive octenidine hydrochloride may be an alternative to chlorhexidine in its ability to control the periodontal parameters in patients with stage I-II periodontitis. Further larger studies are necessary to confirm these findings.

THE HEALTH IMPACT OF TOURISM ON THE PSYCHOPHYSICAL STATE OF ELDERLY INDIVIDUALS

The purpose of our research is to ascertain the impact of tourism activities on the psychophysical state of elderly individuals. Materials and methods. 221 people took part in the transformative experiment aged 60-65, who attend the University of the Third Age (152 women and 69 men). It is worth mentioning that the frequency of classes at the University of the Third Age was 3 classes per week, lasting 40-60 minutes. The program is designed for 6 months and consists of preparatory (adaptation), main (improvement) and supporting periods. Each of the periods was aimed at achieving a set of tasks. To assess the quality of life SF-36 was used. To assess the satisfaction of the participants' lives, the Life Satisfaction Index (LSIA). Physical activity was evaluated using the PWC150 test. The level of success in psychosocial adaptation was assessed using a modified Rogers and Diamond questionnaire. Mind performance was assessed using Bourdon's correction test. The Wilcoxon test was used to analyze the statistical significance of the differences between the data. In each case, the hypothesis was tested, and the p-value was calculated. Conclusions regarding the significance of testing were made at the 0.05 significance level. In the conditions of the University of the Third Age, during the implementation of the concept, positive dynamics of indicators of motor activity, quality and satisfaction with life, mental and physical working capacity, rates of aging, socio-psychological adaptation, cognitive functions, psycho-emotional state were fixed. However, we note significant changes in integral indicators of socio-psychological adaptation at the end of the study, namely, in the indicators of self-perception (women – 68.8 ± 0.7 points; men – 78.8 ± 4.1 points) and emotional comfort (women 63.3 ± 1.7 points ; men 69.2 ± 1.2 points) (p=0.05). As was anticipated, for elderly individuals who continue self-education in their later years, the tourism program had a positive impact on cognitive functioning indicators. Conclusion. Involvement in health tourism has a positive impact on the psychophysical state of elderly individuals. The combination of physical activity, social interaction and the acquisition of new experiences contributes to the improvement of emotional, physical and cognitive health.

Theranova versus FX80: The impact on anemia management in hemodialysis.

Middle uremic toxins (MUTs) can cause anemia and erythropoietin hyporesponsiveness. Theranova dialyzers may improve anemia management by removing MUTs. Hence, the impact of Theranova dialyzers on erythropoietin responsiveness was studied. This exploratory single-center prospective observational study, encompassing 50 patients undergoing dialysis with either the Theranova-400 or FX80 membrane for 6 months, involved monthly tracking of hemoglobin levels, weight-adjusted erythropoiesis-stimulating agent (w-ESA) dosing, and erythropoietin resistance index (ERI), with ESA treatment decisions guided by a proprietary algorithm. The groups were similar in terms of demographics and baseline laboratory test results. The median hemoglobin levels, w-ESA and ERI, were found to be similar between FX80 and Theranova-400 groups at both baseline (11.06 vs 10.57, p = 0.808; 92.3 vs 105.2, p = 0.838; 8.1 vs 10.48, p = 0.876) and the end of the study (11.43 vs 11.03, p = 0.076; 48.7 vs 71.5; 4.48 vs 6.41, p = 0.310), respectively. There was a trend toward lower w-ESA and ERI at the end of the study compared to baseline in both groups, but the difference was non-significant. Based on this study of 50 patients undergoing high-flux dialysis with near-target hemoglobin levels, switching to Theranova 400 dialyzers compared to FX80 dialyzers did not show statistically significant differences in maintaining hemoglobin levels, reducing ESA dose, or lowering ERI. The non-randomized design and small sample size limit the study's power to detect true differences. Larger, randomized trials are needed to confirm findings and definitively assess Theranova 400's benefits.

Changes in oral functions and speech when using custom-fitted mouthguards: An uncontrolled before-and-after study.

Mouthguards are crucial for protecting athletes against orofacial injuries, yet concerns persist regarding their potential impact on oral functions. This study aimed to investigate the effects of sports mouthguards on oral functions and speech over time. Thirty national rugby players received custom-fitted mouthguards. Questionnaire responses and speech recordings were collected before mouthguard use and at various intervals after using mouthguards: immediately, 1 week, 2 month, and 6 months. Spectrographic analysis was performed to measure voice onset time (VOT) for /p, b, t, d/ phonemes. Questionnaire responses were assessed with Friedman's test, while VOT changes were examined using one-way repeated measure analysis of variance. Compliance with mouthguard use improved during training and competitions, with consistent wear reported during matches. Over time, speaking difficulties and lisping decreased significantly (p < .001). The perception of nausea improved (p < .001), stabilizing after 1 month (p = .414). Sensations of bulkiness declined (p < .001). Mouth dryness reduced steadily, with no occurrences reported by all players by the end of the study. None of the participants reported bad breath, ulcers, or redness in the mouth. VOT changed immediately after wearing mouthguards (p < .001), gradually regressing toward the baseline, although not completely reaching it. Players held a favorable view of mouthguard use, with comfort and support for mandatory use increasing over time. Custom-fitted mouthguards do not lead to significant long-term disruptions in oral functions. Athletes generally adapt to mouthguard use, reporting improved comfort and greater support for their use.

Investigation of treatment volume versus circulating blood volume during Rheocarna treatment.

Rheocarna's therapeutic effect is associated with fibrinogen (Fib) and low-density lipoprotein cholesterol (LDL-C) adsorptive removal. This study aimed to retrospectively investigate the association between treatment volume (TV) and circulating blood volume (CBV) and the Fib removal rate (Fib-RR) and LDL-C-RR. CBV and TV/CBV, cut-off value (CO value), and area under the receiver operating characteristic (ROC) curve (AUC) were calculated. The Fib-RR and LDL-C-RR at the midterm and end of treatment were compared. The groups were further categorized into three groups with TV/CBV lower than or higher than the CO value at the midterm and end (midterm/end; Group L: lower than/lower than CO; Group L/H: lower than/higher than CO; Group H: higher than/higher than CO), and the Fib-RR and LDL-RR of each group at the midterm and end were compared. ROC analysis revealed a TV of 1.480 times the BV as CO value, which showed a maximum Youden index predicting a Fib-RR of 20% (AUC: 0.828). Among the three groups, Group L and Group L/H demonstrated significantly higher Fib-RR and LDL-C-RR at the end of the study than in the midterm, while Group H exhibited no difference. The results reveal that a treatment volume of 1.5 times the circulating blood volume is a sufficient solute removal capacity in the Rheocarna-enabled cases.

The effects of a real-time temperature monitoring non-ablative monopolar radiofrequency technology on vulvovaginal atrophy symptoms in postmenopausal Chinese women.

Vulvovaginal atrophy (VVA) includes a wide range of conditions affecting the reproductive and urinary systems, often requiring careful evaluation and management for optimal health. This study aims to evaluate the symptom management effects of a real time temperature-monitored non-ablative RF device for the treatment of postmenopausal Chinese women with VVA symptoms. This pilot study involved 24 postmenopausal Chinese women with one or more VVA symptoms, who wished to remain sexually active. VHIS, VAS, and FSFI were used to track and evaluate various aspects of the patient's condition. Analyses were conducted at the end of the study to verify the statistical significance of the treatment's results. All patients reported substantial, statistically significant, improvements on every VVA symptom tracked. Approximately 80% of the patients reported total symptom reversal at 12-week post-treatment follow-up. This pilot study demonstrated that non-ablative, monopolar RF technology equipped with real time temperature monitoring is feasible and safe in the treatment of postmenopausal women with VVA symptoms, and efficacious at up to 12 weeks post-treatment.